Pubmed Search Author: Sabatini BL



1. Tritsch NX, Oh WJ, Gu C, Sabatini BL. (2014) Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. Elife (Cambridge). 2014
2.  Chen Y, Saulnier JL, Yellen G, Sabatini BL. (2014) A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging. Front Pharmacol. 2014 Apr 2;5:56. 
3. Takasaki K, Sabatini BL. (2014) Super-resolution 2-photon microscopy reveals that the morphology of each dendritic spine correlates with diffusive but not synaptic properties. Front Neuroanat. 2014 May 7;8:29
4. Pisanello F, Sileo L, Oldenburg IA, Pisanello M, Martiradonna L, Assad JA, Sabatini BL, De Vittorio M. (2014) Multipoint-emitting optical fibers for spatially addressable in vivo optogenetics. Neuron. 2014 Jun 18;82(6):1245-54
5. Straub C, Tritsch NX, Hagan NA, Gu C, Sabatini BL. (2014) Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents. J Neurosci. 2014 Jun 18;34(25):8557-69.
6. Straub C, Granger AJ, Saulnier JL, Sabatini BL. (2014) CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons. PLoS One. Aug 20;9(8):e105584. 
7. Khibnik LA, Tritsch NX, Sabatini BL. A direct projection from mouse primary visual cortex to dorsomedial striatum. PLoS One, 2014 Aug 20;9(8):e104501
8. Hochbaum DR, Zhao Y, Farhi SL, Klapoetke N, Werley CA, Kapoor V, Zou P, Kralj JM, Maclaurin D, Smedemark-Margulies N, Saulnier JL, Boulting GL, Straub C, Cho YK, Melkonian M, Wong GK, Harrison DJ, Murthy VN, Sabatini BL, Boyden ES, Campbell RE, Cohen AE. (2014) All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins. Nat Methods. 2014 Aug;11(8):825-33
9. Nieland TJ, Logan DJ, Saulnier J, Lam D, Johnson C, Root DE, Carpenter AE, Sabatini BL. (2014) High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons. PLoS One. 2014 Mar 14;9(3):e91744
10. Murphy JA, Stein IS, Lau CG, Peixoto RT, Aman TK, Kaneko N, Aromolaran K, Saulnier JL, Popescu GK, Sabatini BL, Hell JW, Zukin RS. (2014) Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2+ signaling in spines. J Neurosci. 2014 Jan 15;34(3):869-79


1. Beier KT, Saunders AB, Oldenburg IA, Sabatini BL, Cepko CL. Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo. Front Neural Circuits. 2013;7:11. Paper
2. Takasaki KT, Ding JB Sabatini BL. Live-Cell Superresolution Imaging by Pulsed STED Two-Photon Excitation Microscopy. Biophysical Journal 104:770 PDF Commentary
3.Gross GG, Junge JA, Mora RJ, Kwon HB, Olson CA, Takahashi TT, Liman ER,Ellis-Davies GC, McGee AW, Sabatini BL, Roberts RW, Arnold DB. Recombinant probes for visualizing endogenous synaptic proteins in living neurons. Neuron. 2013 Jun 19;78(6):971-85.
4. Bateup HS, Johnson CA, Denefrio CL, Saulnier JL, Kornacker K, Sabatini BL. Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis. Neuron. 2013 May 8;78(3):510-22. PubMed Central PMCID: PMC3690324.
5. Olson JP, Kwon HB, Takasaki KT, Chiu CQ, Higley MJ, Sabatini BL, Ellis-Davies GC. Optically selective two-photon uncaging of glutamate at 900 nm. J Am Chem Soc. 2013 Apr 24;135(16):5954-7.
6. Banghart MR, Williams JT, Shah RC, Lavis LD, Sabatini BL. Caged Naloxone Reveals Opioid Signaling Deactivation Kinetics. Mol Pharmacol. 2013 Aug 19. [Epub ahead of print] PubMed PMID: 23960100.
7.Tang JC, Szikra T, Kozorovitskiy Y, Teixiera M, Sabatini BL, Roska B, Cepko CL. A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation. Cell. 2013 Aug 15;154(4):928-39. doi: 10.1016/j.cell.2013.07.021. PubMed PMID: 23953120.




1. Banghart MR & Sabatini BL (2012) Photoactivatable Neuropeptides for Spatiotemporally Precise Delivery of Opioids in Neural Tissue. Neuron 73(2):249-259. PDF
2. Liu T, Kong D, Shah BP, Ye C, Koda S, Saunders A, Ding JB, Yang Z, Sabatini BL, Lowell BB (2012) Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone. Neuron 73(3):511-22. PDF
3. Higley MJ, Sabatini BL (2012) Calcium Signaling in Dendritic Spines. Cold Spring Harbor Perspect Biol. 4(4)
4. Sheng M, Sabatini BL, Südhof TC (2012) Synapses and Alzheimer’s disease. Cold Spring Harb Perspect Biol. 4(5).
5. Chen Y, Sabatini BL (2012) Signaling in dendritic spines and spine microdomains. Curr Opin Neurobiol. 22(3):389-96. PDF
6. Kozorovitskiy Y, Saunders A, Johnson CA, Lowell BB & Sabatini BL (2012) Recurrent network activity drives striatal synaptogenesis. Nature 485, 646–650 (31 May 2012) Published online 13 May 2012. PDF

7. Saunders, A., Johnson, C. and Sabatini, B.L. (2012) Novel recombinant adeno-associated viruses for Cre activated and inactivated transgene expression. Front. in Neural Circuits 6:47. PDF
8. Carter BC, Giessel AJ, Sabatini BL, Bean BP. Transient Sodium Current at Subthreshold Voltages: Activation by EPSP Waveforms. Neuron. 2012 Sep 20;75(6):1081-93. doi: 10.1016/j.neuron.2012.08.033. PubMed Central PMCID: PMC3460524
9. Tritsch NX, Ding JB, Sabatini BL. Dopaminergic neurons inhibit striatal output through non-canonical release of GABA. Nature. 2012 Oct 11;490(7419):262-6.
10.Tritsch NX, Sabatini BL. Dopaminergic modulation of synaptic transmission in cortex and striatum. Neuron. 2012 Oct 4;76(1):33-50.
11.Kwon HB, Kozorovitskiy Y, Oh WJ, Peixoto RT, Akhtar N, Saulnier JL, Gu C, Sabatini BL. Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number. Nat Neurosci. 2012 Nov 11.
12.Peixoto RT, Kunz PA, Kwon H, Mabb AM, Sabatini BL, Philpot BD, Ehlers MD. Transsynaptic signaling by activity-dependent cleavage of neuroligin-1. Neuron. 76(2):396-409.
13.Carter BC, Giessel AJ, Sabatini BL, Bean BP. Transient Sodium Current at Subthreshold Voltages: Activation by EPSP Waveforms. Neuron. 75(6):1081-93.



1. Bateup HS, Takasaki KT, Saulnier JL, Denefrio CL, Sabatini BL (2011) Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function. Journal of Neuroscience 31: 8862-8869. PDF
2. Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL. (2011) Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A 108: 15414-15419. PDF
3. Ding JB, Oh WJ, Sabatini BL, Gu C (2011) Semaphorin 3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum. Nature Neuroscience Dec 18;15(2):215-23. PDF
4. Giessel AJ, Sabatini BL (2011) Boosting of synaptic potentials and spine Ca transients by the peptide toxin SNX-482 requires alpha-1E-encoded voltage-gated Ca channels. PLoS One 6: e20939. PDF
5. Goda Y, Sabatini BL (2011) Synaptic function and regulation. Curr Opin Neurobiol 21: 205-207. PDF
6. Higley MJ, Gittis AH, Oldenburg IA, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, Sabatini BL. (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6: e19155. PDF
7. Kwon HB, Sabatini BL (2011) Glutamate induces de novo growth of functional spines in developing cortex. Nature 474: 100-104. PDF
8. Sigrist SJ, Sabatini BL (2011) Optical super-resolution microscopy in neurobiology. Curr Opin Neurobiol. PDF



1. Bateup HS, Sabatini BL (2010) For synapses, it’s depression not death. Cell 141: 750-752.
2. Cheng J, Zhou X, Miller EL, Alvarez VA, Sabatini BL, et al. (2010) Oriented Markov random field based dendritic spine segmentation for fluorescence microscopy images. Neuroinformatics 8: 157-170.
3. Giessel AJ, Sabatini BL (2010) M1 muscarinic receptors boost synaptic potentials and calcium influx in dendritic spines by inhibiting postsynaptic SK channels. Neuron 68: 936-947. PDF
4. Higley MJ, Sabatini BL (2010) Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nature Neuroscience 13: 958-966. PDF



1. Beck D, Zhou X, Pham T, Sabatini B, Wong ST (2009) An Image Driven Systems Biology Approach for Neurodegenerative Disease Studies in the TSC-mTOR Pathway. IEEE NIH Life Sci Syst Appl Workshop: 36-39.
2. Bloodgood BL, Giessel AJ, Sabatini BL (2009) Biphasic synaptic Ca influx arising from compartmentalized electrical signals in dendritic spines. PLoS Biology 7: e1000190. PDF
3. Bloodgood BL, Sabatini BL (2009) NMDA Receptor-Mediated Calcium Transients in Dendritic Spines.  In: Van Dongen AM, editor. Biology of the NMDA Receptor. Boca Raton (FL): CRC Press; 2009. Chapter 9.
4. Ding JB, Takasaki KT, Sabatini BL (2009) Supraresolution imaging in brain slices using stimulated-emission depletion two-photon laser scanning microscopy. Neuron 63: 429-437.  PDF Cover
5. Higley MJ, Soler-Llavina GJ, Sabatini BL (2009) Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration. Nature Neuroscience 12: 1121-11 28. PDF
6. Sturgill JF, Steiner P, Czervionke BL, Sabatini BL (2009) Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking. Journal of Neuroscience 29: 12845-12854. PDF



1. Alvarez VA, Shankar GM, Bloodgood BL, Selkoe DJ, Sabatini BL (2008) Multiple levels of synaptic regulation by NMDA-type glutamate receptors in normal and disease states. In: Selkoe DJ, Triller A, Christen Y, editors. Synaptic plasticity and the mechanism of Alzheimer’s disease. Berlin: Springer.
2. Bloodgood BL, Sabatini BL (2008) Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. J Physiol 586: 1475-1480. PDF
3. Busetto G, Higley MJ, Sabatini BL (2008) Developmental presence and disappearance of postsynaptically silent synapses on dendritic spines of rat layer 2/3 pyramidal neurons. J Physiol 15;586(6):1519-27 PDF
4. Carter AG, Sabatini BL (2008) Spine calcium signaling. In: Stuart G, Spruston N, Hausser M, editors. Dendrites. second ed. Oxford: Oxford University Press.

5. Han S, Witt RM, Santos TM, Polizzano C, Sabatini BL, Ramesh V. (2008) Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling. Cell Signal 20: 1084-1091. PDF
6. Higley MJ, Sabatini BL (2008) Calcium signaling in dendrites and spines: practical and functional considerations. Neuron 59: 902-913. PDF
7. Sabatini BL, Svoboda K (2008) Ca2+ Signaling in Dendritic Spines In: Ehlers MD, Hell JW, editors. Structural and Functional Organization of the Synapse: Springer.
8. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, et al. (2008) Amyloid-beta protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory. Nat Med 14: 837-842. PDF
9. Steiner P, Higley MJ, Xu W, Czervionke BL, Malenka RC, Sabatini BL. (2008) Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity. Neuron 60: 788-802. PDF

10. Xu W, Schluter OM, Steiner P, Czervionke BL, Sabatini B, Malenka RC. (2008) Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron 57: 248-262. PDF



1. Alvarez VA, Ridenour DA, Sabatini BL (2007) Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability. J Neurosci 27: 7365-7376. PDF Cover
2. Alvarez VA, Sabatini BL (2007) Anatomical and physiological plasticity of dendritic spines. Annu Rev Neurosci 30: 79-97. PDF

3. Bloodgood BL, Sabatini BL (2007) Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines. Neuron 53: 249-260. PDF
4. Bloodgood BL, Sabatini BL (2007) Ca(2+) signaling in dendritic spines. Curr Opin Neurobiol 17: 345-351. PDF

5. Carter AG, Soler-Llavina GJ, Sabatini BL (2007) Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. J Neurosci 27: 8967-8977. PDF Cover
6. Cheng J, Zhou X, Miller E, Witt RM, Zhu J, et al. (2007) A novel computational approach for automatic dendrite spines detection in two-photon laser scan microscopy. J Neurosci Methods 165: 122-134.
7. Sabatini BL (2007) Neuroscience: neighbourly synapses. Nature 450: 1173-1175.
8. Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. (2007) Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 27: 2866-2875. PDF
9. Zhang Y, Zhou X, Witt RM, Sabatini BL, Adjeroh D, et al. (2007) Dendritic spine detection using curvilinear structure detector and LDA classifier. Neuroimage 36: 346-360.



1. Alvarez VA, Ridenour DA, Sabatini BL (2006) Retraction of synapses and dendritic spines induced by off-target effects of RNA interference. J Neurosci 26: 7820-7825. PDF
NOTE: This paper was not retracted!  The title just starts with that word.  Never do that!
2. Soler-Llavina GJ, Sabatini BL (2006) Synapse-specific plasticity and compartmentalized signaling in cerebellar stellate cells. Nat Neurosci. 9(6):798-806 PDF
3. Zhou X, Zhu J, Liu KY, Sabatini BL, Wong ST (2006) Mutual information-based feature selection in studying perturbation of dendritic structure caused by TSC2 inactivation. Neuroinformatics 4: 81-94.



1. Bloodgood BL, Sabatini BL (2005) Neuronal activity regulates diffusion across the neck of dendritic spines. Science 310: 866-869. PDF
2. Ngo-Anh TJ, Bloodgood BL, Lin M, Sabatini BL, Maylie J, Adelman JP. (2005) SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines. Nature Neuroscience 8: 642-649. PDF

3. Tavazoie SF, Alvarez VA, Ridenour DA, Kwiatkowski DJ, Sabatini BL (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nature Neuroscience 8: 1727-1734. PDF



1. Carter AG, Sabatini BL (2004) State-dependent calcium signaling in dendritic spines of striatal medium spiny neurons. Neuron 44: 483-493. PDF


Sabatini postdoc (with Karel Svoboda), graduate school (with Wade Regehr), and undergrad summer (with Steven Siegelbaum)

Yasuda R, Nimchinsky EA, Scheuss V, Pologruto TA, Oertner TG, et al. (2004) Imaging calcium concentration dynamics in small neuronal compartments. Sci STKE 2004: pl5. PDF

Pologruto TA, Sabatini BL, Svoboda K (2003) ScanImage: flexible software for operating laser scanning microscopes. Biomed Eng Online 2:13 PDF ScanImage@Janelia

Yasuda R, Sabatini BL, Svoboda K (2003) Plasticity of calcium channels in dendritic spines. Nat Neurosci 6: 948-955. PDF

Nimchinsky EA, Sabatini BL, Svoboda K (2002) Structure and function of dendritic spines. Annu Rev Physiol 64: 313-353. PDF

Oertner TG, Sabatini BL, Nimchinsky EA, Svoboda K (2002) Facilitation at single synapses probed with optical quantal analysis. Nat Neurosci 5: 657-664. PDF

Sabatini BL, Oertner TG, Svoboda K (2002) The life cycle of Ca(2+) ions in dendritic spines. Neuron 33: 439-452. PDF

Sabatini BL, Maravall M, Svoboda K (2001) Ca(2+) signaling in dendritic spines. Curr Opin Neurobiol 11: 349-356. PDF

Maravall M, Mainen ZF, Sabatini BL, Svoboda K (2000) Estimating intracellular calcium concentrations and buffering without wavelength ratioing. Biophys J 78: 2655-2667. PDF

Sabatini BL, Svoboda K (2000) Analysis of calcium channels in single spines using optical fluctuation analysis. Nature 408: 589-593. PDF

Sabatini BL, Regehr WG (1999) Timing of synaptic transmission. Annu Rev Physiol 61: 521-542. PDF

Sabatini BL, Regehr WG (1998) Optical measurement of presynaptic calcium currents. Biophys J 74: 1549-1563. PDF

Sabatini BL, Regehr WG (1997) Control of neurotransmitter release by presynaptic waveform at the granule cell to Purkinje cell synapse. J Neurosci 17: 3425-3435. PDF

Sabatini BL, Regehr WG (1996) Timing of neurotransmission at fast synapses in the mammalian brain. Nature 384: 170-172. PDF

Mintz IM, Sabatini BL, Regehr WG (1995) Calcium control of transmitter release at a cerebellar synapse. Neuron 15: 675-688. PDF

Sabatini BL, Regehr WG (1995) Detecting changes in calcium influx which contribute to synaptic modulation in mammalian brain slice. Neuropharmacology 34: 1453-1467. PDF

Blumenfeld H, Zablow L, Sabatini B (1992) Evaluation of cellular mechanisms for modulation of calcium transients using a mathematical model of fura-2 Ca2+ imaging in Aplysia sensory neurons. Biophys J 63: 1146-1164. PDF


June 30th, 2011


Howard Hughes Medical Institute
Department of Neurobiology
Harvard Medical School
220 Longwood Ave
Boston, MA 02115
Howard Hughes Medical Institute
Harvard Medical School