Positive and negative synaptogenic signals

In a collaboration with the Gu lab, Jun Ding and Won-Jong Oh demonstrate that Plexin-D1 is expressed by direct pathway medium spiny neurons and limits their post-natal innervation by thalamic axons (PDF).  In contrast,  Hyungabe Kwon found that glutamate stimulation is sufficient to quickly (<20 seconds!) generate new synapses and dendritic spines in cortical layer 2/3 pyramidal neurons (PDF).

January 24th, 2012

Address

Howard Hughes Medical Institute
Department of Neurobiology
Harvard Medical School
220 Longwood Ave
Boston, MA 02115
Howard Hughes Medical Institute
Harvard Medical School