TSC, Fragile X, and mGluR LTD

Helen Bateup published that the TSC1 protein, which is often mutated in people Tuberous Sclerosis Complex (TSC), is necessary for metabotropic glutamate receptor dependent long-term depression (mGluR LTD) in the hippocampus.  This is very interesting because both TSC and Fragile X Syndrome are autism spectrum disorders that are caused by loss of a negative regulator of protein translation.  However, in mouse models of TSC mGluR LTD is lost whereas in models of Fragile X it is enhanced.  Two models of autism show perturbed plasticity, but in different directions.

January 21st, 2012

Address

Howard Hughes Medical Institute
Department of Neurobiology
Harvard Medical School
220 Longwood Ave
Boston, MA 02115
Howard Hughes Medical Institute
Harvard Medical School