In the first few years of life, humans tremendously expand their behavioral repertoire and gain the ability to engage in complex, learned, and reward-driven actions. Similarly, within a few weeks after birth mice can perform sophisticated spatial navigation, forage independently for food, and engage in reward reinforcement learning. Our laboratory seeks to uncover the mechanisms of synapse and circuit plasticity that permit new behaviors to be learned and refined. We are interested in the developmental changes that occur after birth that make learning possible as well as in the circuit changes that are triggered by the process of learning. Lastly, we examine how perturbations of these processes contribute to human neuropsychiatric disorders such as Tuberous Sclerosis Complex and Parkinson’s Disease.
- Our latest work is now on available. Cell-type specific asynchronous modulation of PKA by dopamine during reward based learning t.co/pFJQWA1CUV This is collaborative work led by no-twitter MD/PhD student Suk Joon Lee with @yaochen20 @LinTianLab @SabatiniLab
- And, I think, our final @sabatinilab paper with @neurodev_lab (Rui Peixoto) who is now leading his own lab at U. Pitt. Also involves striatal PKA! Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B−/− Mice t.co/NRwYqnIEks
- Big effort by @ajgrange and company from @SabatiniLab on cortical cholinergic VIP cells is now on biorxiv t.co/N5drYvlgKP
The main gate to the city of Lecce. From there you find a city full of Baroque lime stone buildings and large cobble stone streets. t.co/vmsLuLX3Jw
- Heading to Optogen 2017 Always a delight to visit Lecce @blsabatini t.co/I4ZoRfWmOq