In the first few years of life, humans tremendously expand their behavioral repertoire and gain the ability to engage in complex, learned, and reward-driven actions. Similarly, within a few weeks after birth mice can perform sophisticated spatial navigation, forage independently for food, and engage in reward reinforcement learning. Our laboratory seeks to uncover the mechanisms of synapse and circuit plasticity that permit new behaviors to be learned and refined. We are interested in the developmental changes that occur after birth that make learning possible as well as in the circuit changes that are triggered by the process of learning. Lastly, we examine how perturbations of these processes contribute to human neuropsychiatric disorders such as Tuberous Sclerosis Complex and Parkinson’s Disease.
- Big effort by @ajgrange and company from @SabatiniLab on cortical cholinergic VIP cells is now on biorxiv t.co/N5drYvlgKP
The main gate to the city of Lecce. From there you find a city full of Baroque lime stone buildings and large cobble stone streets. t.co/vmsLuLX3Jw
- Heading to Optogen 2017 Always a delight to visit Lecce @blsabatini t.co/I4ZoRfWmOq
- The free link to the final version of our Gaq-GPCR->PKA paper is now available at Neuron. Please share. Link gives free downloads and access. t.co/w21nCzU04G
Another view. Montana plate on the back. Apparently $2M+ price t.co/6Gfxgk1s3x