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Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration

Journal Article

Animals adapt to environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of organs throughout the body. Here, we find that...

Social isolation uncovers a circuit underlying context-dependent territory-covering micturition.

Journal Article

The release of urine, or micturition, serves a fundamental physiological function and, in many species, is critical for social communication. In mice, the pattern of urine release is modulated by external and internal factors and transmitted to the spinal...

Thyroid hormone rewires cortical circuits to coordinate body-wide metabolism and exploratory drive

Journal Article

Animals adapt to varying environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of organs throughout the body. Here we find...

Social isolation uncovers a circuit underlying context-dependent territory-covering micturition

Journal Article

The release of urine, or micturition, serves a fundamental physiological function and, in many species, is critical for social communication. In mice, the pattern of urine release is modulated by external and internal factors and transmitted to the spinal...

Mythri Majahan

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Linda Lin

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Mice exhibit stochastic and efficient action switching during probabilistic decision making

Journal Article

In probabilistic and nonstationary environments, individuals must use internal and external cues to flexibly make decisions that lead to desirable outcomes. To gain insight into the process by which animals choose between actions, we trained mice in a...

Detecting changes in calcium influx which contribute to synaptic modulation in mammalian brain slice

Journal Article

The control of neurotransmitter release by modulation of presynaptic calcium influx was investigated at the granule cell to Purkinje cell synapse in rat cerebellar slices. Excitatory post-synaptic currents were measured using whole cell voltage clamp, and...

Alaina Fernandes

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Alex Maropakis

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Bernardo Sabatini Lab

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In the first few years of life, humans tremendously expand their behavioral repertoire and gain the ability to engage in complex, learned, and reward-driven actions. Similarly, within a few weeks after birth mice can perform sophisticated spatial...